Complement Evasion Borrelia burgdorferi
Classical pathway: protein C1q binds to the pathogen surface activating complement C4 and C2.
Lectin pathway: mannose-binding lectin or ficolin (in complex with serine protease and small mannose-binding lectin associated protein) bind to polysaccharids on the pathogen’s surface.
Alternative pathway: in this case the continuous spontaneous hydrolysis of C3 into C3-H2O is involved. The latter binds and stabilizes the alternative C3 convertase C3bBb.