Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Complement Evasion Borrelia burgdorferi

  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_4588-1
Borreliosis is one of the most common tick-borne diseases in man and animals. Recent studies have shown that there are three pathways to activate complement on the outer membrane of B. burgdorferi and thus to initiate defense mechanisms.
  • Classical pathway: protein C1q binds to the pathogen surface activating complement C4 and C2.

  • Lectin pathway: mannose-binding lectin or ficolin (in complex with serine protease and small mannose-binding lectin associated protein) bind to polysaccharids on the pathogen’s surface.

  • Alternative pathway: in this case the continuous spontaneous hydrolysis of C3 into C3-H2O is involved. The latter binds and stabilizes the alternative C3 convertase C3bBb.


Defense Mechanism Outer Membrane Serine Protease Alternative Pathway Associate Protein 
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Further Reading

  1. Talye D et al (2013) Complement evasion by Borrelia burgdorferi: it takes three to tango. Trends Parasitol 29:119–128CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany