Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Chloroquine New Treatment Regimens

  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_4582-1

The use and efficacy of the old first-line antimalarial compound was based on nanomolar levels of the drug inside a treated person. This led to the development of the well-known recent resistances in many regions of the world. However, some research groups showed when patients used chloroquine in a way that offers micromolar levels that this way led to other pathways of efficacy. The results of an increased efficacy, but also the treatment risks, are summarized in the review of Ch’ng et al. (2012).


Research Group Treatment Regimen Treated Person Treatment Risk Micromolar Level 
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  1. Ch’ng JH et al (2012) Can we teach an old drug new tricks? Trends Parasitol 28:220–224CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany