Chloroquine New Treatment Regimens
The use and efficacy of the old first-line antimalarial compound was based on nanomolar levels of the drug inside a treated person. This led to the development of the well-known recent resistances in many regions of the world. However, some research groups showed when patients used chloroquine in a way that offers micromolar levels that this way led to other pathways of efficacy. The results of an increased efficacy, but also the treatment risks, are summarized in the review of Ch’ng et al. (2012).