Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Artemisinin: Modes of Action

  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_4527-1
The modern antimalarial compound artemisinin ( Quinghaosu) is claimed to act in the following ways after being activated through cleavage of the intrinsic bond:
  1. 1.

    Interference with the heme detoxification pathway

  2. 2.

    Induction of the alkylation of the translationally controlled tumor protein (PfTCTP) and of other proteins

  3. 3.

    Inhibition of the sarco/endoplasmic reticulum membrane calcium APPase6

  4. 4.

    Inference with Plasmodium mitochondrial functions



Mitochondrial Function Control Tumor Tumor Protein Detoxification Pathway Antimalarial Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading

  1. Ding XC et al (2011) Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets. Trends Parasitol 27:73–81CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany