Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn


  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_4468-1

Medicaments developed to treat human trypanosomiasis. The first was aminophenyl arsonic acid (named Atoxyl) being introduced around 1905. Around 1920, it was replaced by the less toxic arsonophenylglycineamide (tryparsamide). In the 1940s, both were replaced by melarsoprol.


Arsonic Acid Aminophenyl Arsonic Acid Human Trypanosomiasis 
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Further Reading

  1. Friedheim EA (1948) Melarsenoxide in the treatment of human trypanosomiasis. Ann Trop Med Parasitol 42:357–363CrossRefPubMedGoogle Scholar
  2. Jacobs WA, Heidelberger M (1919) Chemotherapy of trypanosome and spirochete infections: chemical series. I. N-phenylglycineamide-p-arsonic acid. J Exp Med 30:411–415CrossRefPubMedPubMedCentralGoogle Scholar
  3. Thomas HW (1905) Some experiments in the treatment of trypanosomiasis. Br Med J 1:1140–1143CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany