Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Antioxidants

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_4464-1
Oxidative damage is one of the most relevant pathological effects in human Plasmodium infections as well as in other parasitoses. Therefore, a number of known antioxidants, such as vitamins C and E, desferroxamines, folate, N-Acetylcystein, etc., have been tested. Some promising results are collected in Table 1 by Isah and Ibrahim ( 2014) and should stimulate for further research in antiparasitic compounds.
Table 1

Effects of different antioxidants on Plasmodium infections and its associated oxidative damage

Antioxidant

Plasmodium species

Effect on parasitemia

Effect on oxidative damage

Vitamin E

P. berghei

NE

Vitamin C

P. berghei

ND

P. falciparum

P. falciparum

NE

ND

N-Acetylcystein

P. berghei

P. berghei and P. yoelii

NE

P. falciparum

ND

P. falciparum

NE

ND

Folate

P. berghei

ND

Desferroxamine

P. falciparum

ND

P. falciparum

ND

P. berghei

P. falciparum and P. vivax

ND

P. falciparum

ND

P. berghei and P. yoelii

NE

ND

Dequalinium

P. berghei

ND

P. berghei

Vi...

Keywords

Oxidative Damage Promising Result Pathological Effect Plasmodium Infection Human Plasmodium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Isah MB, Ibrahim MA (2014) The role of antioxidants treatment on the pathogenesis of malarial infections: a review. Parasitol Res 113:801–809CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany