This compound is used in Africa for intermittent preventive therapy in pregnant women (IPTp) and infants (IPTi). The resistance of some Plasmodium falciparum strains against a treatment with sulfadoxine pyrimethamine is due to the fact that resistant strains show a mutation in the genes Pfdhfr (P. falciparum dihydrofolate reductase) and Pfdhps (P. falciparum dihydropteroate synthase). These apparently progressing resistances endanger any mass treatment. In three foci of East Africa the populations are already fully resistant.
Further Reading
Naidoo I, Roper C (2013) Mapping partially resistant, fully resistant, and super resistant malaria. Trends Parasitol 29:505–515
Venkatesan M et al (2013) Monitoring antifolate resistance in intermittent preventive therapy for malaria. Trends Parasitol 29:497–504
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Mehlhorn, H. (2015). Sulfadoxine Pyrimethamine Resistance. In: Mehlhorn, H. (eds) Encyclopedia of Parasitology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27769-6_4358-1
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DOI: https://doi.org/10.1007/978-3-642-27769-6_4358-1
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