Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Sulfadoxine Pyrimethamine Resistance

  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_4358-1

This compound is used in Africa for intermittent preventive therapy in pregnant women (IPTp) and infants (IPTi). The resistance of some Plasmodium falciparum strains against a treatment with sulfadoxine pyrimethamine is due to the fact that resistant strains show a mutation in the genes Pfdhfr (P. falciparum dihydrofolate reductase) and Pfdhps (P. falciparum dihydropteroate synthase). These apparently progressing resistances endanger any mass treatment. In three foci of East Africa the populations are already fully resistant.


Pregnant Woman Plasmodium Falciparum Resistant Strain Preventive Therapy Dihydrofolate Reductase 
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Further Reading

  1. Naidoo I, Roper C (2013) Mapping partially resistant, fully resistant, and super resistant malaria. Trends Parasitol 29:505–515CrossRefPubMedGoogle Scholar
  2. Venkatesan M et al (2013) Monitoring antifolate resistance in intermittent preventive therapy for malaria. Trends Parasitol 29:497–504CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany