Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Malaria-Infected Erythrocyte-Derived Microvesicles (MV’s)

  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_4046-1

In the years since 2010 numerous papers were published showing that the erythrocytes and platelets of humans produce tiny (0.1–1 μm sized) microvesicles as long as an infection with Plasmodium falciparum or P. vivax is persistent in patients. These microvesicles are produced by blebbing of the host plasma membrane. While in infected patients large numbers of these microvesicles can be found, their number is extremely low in uninfected persons. After antimalarial treatment the high number decreases suddenly, reaching lowest numbers on day 14 after treatment. Similar microvesicles occur in cases of diseases such as cardiovascular disturbance, arthritis, thalassemia or tumor outbreaks. Flow assays by help of antibodies against the parasite antigen RESA (being situated below the host cell membrane in malaria patients) proved that this protein is apparently included inside these microvesicles. Experiments with Plasmodium bergheiof rodents showed that these MV’s introduce inflammatory...

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References

  1. Mantel PY et al (2013) Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host Microbe 13:521–534CrossRefPubMedPubMedCentralGoogle Scholar

Further Reading

  1. Nantakomol D et al (2011) Circulation of red-cell derived microparticles in human malaria. J Infect Dis 203:700–706CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany