Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Anaplasma phagocytophilum

  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_3612-1

This organism is a small, 0.4–1.9 μm sized, coccid, pleomorphic, nonmotile, gram-negative bacterium, which lives obligatorily intracellular in the neutrophilic granulocytes and (more rare) in thrombocytes of humans and of other mammals in the USA and in Eurasia (ranging from Portugal to Russia). In the USA Amblyomma americanum ticks are the main vectors, while in Europe and other regions the ticks Ixodes ricinus and Ixodes persulcatus are the proven vectors. In seroepidemiologic tests up to 21 % of endangered humans (e.g., forest workers, etc.) had been found seropositive. The disease in humans is called human granular anaplasmosis (formerly human granular ehrlichiosis, since this bacterium had previously been named Ehrlichia phagocytophilia honoring the German microbiologist Paul Ehrlich). Although about 80 % of the infections lead only to relatively mild symptoms, 20 % of the infected persons may show severe symptoms, which start after an incubation period ranging from a few days to...

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Further Reading

  1. Michalik J et al (2009) Molecular evidence of Anaplasma phagocytophilum infection in wild cervids and feeding Ixodes ricinus ticks from West Central Poland. Clin Microbiol Infect 15:81–83CrossRefPubMedGoogle Scholar
  2. Richter D, Matuschka FR (2012) Candidatus Neoehrlichia mikurensis, Anaplasma phagocytophilum and lyme disease spirochaetes in questing European vector ticks and in feeding ticks removed from people. J Clin Microbiol 50:943–947CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany