Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Reporter Genes in Parasites

  • Nasib Singh
  • Anuradha Dube
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_3511-1

Current Status of Parasitic Infections

Parasitic diseases such as malaria, leishmaniasis, trypanosomiasis, filariasis, and different helminthes infections have remained as serious health problems in different regions of the world. Developing and least developed countries of Asia, Africa, and South American regions are most vulnerable with significant morbidity and mortality. According to recent reports, malaria caused by protozoan parasite Plasmodium spp. affects more than 225 million people with 3 billion people at risk of infection and approximately 700 thousand deaths annually (WHO 2012; Lynch et al. 2012). Plasmodium falciparum is the most common causative agent (WHO-TDR 2013). Similarly, leishmaniasis caused by Leishmania spp. (L. donovani, L. major, L. mexicana, and L. braziliensis) is endemic in 98 countries of five continents with 350 million people at risk of infection and estimated 0.2–0.4 million new cases of VL and 0.7–1.2 million new cases of CL occurring annually. Over...

Keywords

Green Fluorescent Protein Reporter Gene Enhance Green Fluorescent Protein Drug Screening Yellow Fluorescent Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Further Reading

  1. Alvar J, Vélez ID, Bern C, Herrero M, Desjeux P et al (2012) Leishmaniasis worldwide and global estimates of its incidence. PLoS One 7:e35671CrossRefPubMedPubMedCentralGoogle Scholar
  2. Kadekoppala M, Kline K, Akompong T, Haldar K (2000) Stable expression of a new chimeric fluorescent reporter in the human malaria parasite Plasmodium falciparum. Infect Immun 68:2328–2332CrossRefPubMedPubMedCentralGoogle Scholar
  3. Rocha MN, Correa CM, Melo MN, Beverley SM, Martins-Filho OA, Madureira AP, Soares RP (2013) An alternative in vitro drug screening test using Leishmania amazonensis transfected with red fluorescent protein. Diagn Microbiol Infect Dis 75:282–291CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of BiotechnologyEternal UniversitySirmourIndia
  2. 2.Division of ParasitologyCSIR-Central Drug Research InstituteLucknowIndia