Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Malaria, Immune Responses

  • Caroline Lin Lin ChuaEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_3494-1

Protection of the infected host is measured via two parameters: protection against disease and protection against parasitaemia. The acquisition of natural immunity seems to be able to completely protect the host against disease, but is ineffective against eliminating parasites from the host. This is evidenced by reports of asymptomatic malaria infections, which are rather common in regions with high malaria transmission.

Premunition in High Transmission Areas

Multiple re-infections and frequent exposure to malaria can lead to the generation of some protective immunity. This can partially explain why nonimmune travelers are more susceptible to malaria compared to those living in malaria endemic regions. It is intriguing, however, that even individuals in holoendemic (where transmission occurs all year long) and hyperendemic (where high transmission occurs but only during certain seasons) regions do not develop a sterile immunity against malaria (Obi et al. 2010). These individuals may...


Malaria Transmission Malaria Infection Cerebral Malaria Blood Stage Placental Malaria 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Medicine (Royal Melbourne Hospital)The University of MelbourneParkvilleAustralia