Malaria, Monocyte/Macrophage Activities
Living reference work entry
Immunopathology in Malaria
Many clinical consequences of malaria have been attributed to immunopathology. Inflammation is necessary to limit and resolve an infection, yet dysregulated and excessive inflammatory reactions can lead to extensive host damage, sometimes greater than that caused by infection alone. Monocytes/macrophages and their inflammatory products have been implicated in malaria pathogenesis, leading to clinical disease (Fig. 1).
KeywordsCerebral Malaria Infected Erythrocyte IL12B Gene Severe Malarial Anemia Intervillous Space
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- Grau GE, Heremans H, Piguet PF, Pointaire P, Lambert PH, Billiau A, Vassalli P (1989) Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor. Proc Natl Acad Sci 86:5572–5574CrossRefPubMedPubMedCentralGoogle Scholar
- Lyke KE, Burges R, Cissoko Y, Sangare L, Dao M, Diarra I, Kone A, Harley R, Plowe CV, Doumbo OK et al (2004) Serum levels of the proinflammatory cytokines Interleukin-1β (IL-1β), IL-6, IL-8, IL-10, Tumor Necrosis Factor Alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. Infect Immun 72:5630–5637CrossRefPubMedPubMedCentralGoogle Scholar
- Morahan G, Boutlis CS, Huang D, Pain A, Saunders JR, Hobbs MR, Granger DL, Weinberg JB, Peshu N, Mwaikambo ED (2002) A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. Genes Immun 3:414–418CrossRefPubMedGoogle Scholar
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