Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Malaria, Monocyte/Macrophage Activities

  • Caroline Lin Lin ChuaEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_3492-1

Immunopathology in Malaria

Many clinical consequences of malaria have been attributed to immunopathology. Inflammation is necessary to limit and resolve an infection, yet dysregulated and excessive inflammatory reactions can lead to extensive host damage, sometimes greater than that caused by infection alone. Monocytes/macrophages and their inflammatory products have been implicated in malaria pathogenesis, leading to clinical disease (Fig. 1).


Cerebral Malaria Infected Erythrocyte IL12B Gene Severe Malarial Anemia Intervillous Space 
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Further Reading

  1. Idro R, Jenkins NE, Newton CRJC (2005) Pathogenesis, clinical features, and neurological outcome of cerebral malaria. Lancet Neurol 4:827–840CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Medicine (Royal Melbourne Hospital)The University of MelbourneParkvilleAustralia