Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Tubulovesicular Network (TVN)

  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_3316-2

This term describes a system of channels that are induced (e.g., by malaria parasites) on the surface of the parasitophorous vacuole inside the host cell. It is used like the so-called Maurer’s clefts to export a bunch of about 400 secretory proteins into the red blood cell in order to aid in host cell modification. This transport depends on phosphatidylinositol 3-phosphate.


Blood Cell Host Cell Malaria Parasite Secretory Protein Parasitophorous Vacuole 
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Further Reading

  1. Bhattacharjee S et al (2012) Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites. Trends Parasitol 28:555–562PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany