Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn


  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_2065-2


General Information

Nagana is a very important disease of domestic livestock. According to the Food and Agriculture Organization of the United Nations (FAO), it is probably the only disease which has profoundly affected the settlement and economic development of a major part of a continent. Today, it is still endemic in more than 35 African countries and causes huge economic losses (Trypanosoma).


In cattle the pathogenesis is dominated by three features: anemia, tissue lesions, and immunosuppression. The cause of anemia is complex and involves a variety of mechanisms. Although hemolysins are released by trypanosomes, intravascular hemolysis is not a prominent feature, and anemia is rather attributed to erythrophagocytosis by cells of the mononuclear phagocytic system in the spleen, bone marrow, lungs, and lymph nodes. These cells are stimulated by the formation of complexes between immunoglobulin specific for...


Intravascular Hemolysis Intermittent Fever Huge Economic Loss Trypanosome Infection Hair Coat 
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Further Reading

  1. Bouyer J et al (2013) Community- and farmer-based management of animal African trypanosomosis in cattle. Trends Parasitol 29:519–522CrossRefPubMedGoogle Scholar
  2. Silbermayr K et al (2013) A novel qPCR assay for the detection of African animal trypanosomosis in trypanotolerant and trypanosusceptible cattle breeds. PLoS Negl Trop 7(8):e2345CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany