Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn


  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_1635-2

Chemical Class

Macrocyclic lactone (16-membered macrocyclic lactone, avermectins).

Mode of Action

Glutamate-gated chloride channel modulator. Nematocidal Drugs, Ectoparasiticides: Antagonists and Modulators of Chloride Channels.

Ivermectin application increases the release of GABA (γ-aminobutyric acid) at the presynaptic nerve ending leading to the opening of the chloride ion channels and thus increasing the GABA binding at the motor neuron.


Motor Neuron Chloride Channel Chemical Class Channel Modulator Macrocyclic Lactone 
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Further Reading

  1. Dourmishew AL et al (2005) Ivermectin: pharmacology and application in dermatology. Int J Dermatol 44:1981–1988Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany