Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn


  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_11-2
Acanthamoeba spp. have been found in the throat; mouth pipetting of fluids into cell culture has given rise to contaminated cell cultures in numerous instances. In the throat the amoebae appear to be nonpathogenic. However, in patients with long-standing immunosuppression, tissue invasion does occur, usually leading to encephalitis which is fatal and occasionally to focal lesions elsewhere. The inflammation is mononuclear, partially in response to necrosis of brain tissue, and is sometimes stated to be granulomatous; hemorrhage may be marked. Large amoebic trophozoites and smaller cysts with an irregular “corrugated” wall are found in the lesions. Often the amoebae (Figs. 1 and 2) are difficult to distinguish from macrophages; the latter have intensely staining nuclei, whereas the amoebae have vesicular nuclei and a “foamy” cytoplasm. The inflammatory reaction is of course variable because of immunosuppression of the patients ( Pathology). The amoebae are not found in the spinal fluid....


Eutrophic Lake Focal Lesion Acquire Immunodeficiency Syndrome Small Cyst Tissue Invasion 
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Further Reading

  1. Carnt N, Stapleton F (2015) Strategies for the prevention of contact lens-related Acanthamoeba keratitis: a review. Ophthalmic Physiol Opt. doi:10.1111/opo.12271PubMedGoogle Scholar
  2. Derda M et al (2016) Artemisia annua L. as a plant with potential use in the treatment of acanthamoebiasis. Parasitol Res. doi:10.1007/s00436-016-4902-zGoogle Scholar
  3. Rocha-Cabrera P et al (2015) Detection of Acanthamoeba on the ocular surface in a Spanish population using the Schirmer strip test: pathogenic potential, molecular classification and evaluation of the sensitivity to chlorhexidine and voriconazole of the isolated Acanthamoeba strains. J Med Microbiol 64:849–853CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und Parasitologie Universitätsstraße 1DüsseldorfGermany