Encyclopedia of Complexity and Systems Science

Living Edition
| Editors: Robert A. Meyers

DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires

  • Baoquan Ding
  • Yan Liu
  • Sherri Rinker
  • Hao Yan
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27737-5_132-3

Definition of the Subject

DNA self-assembly is a very useful and powerful tool for bottom-up nanofabrication. It consists of combining unusual DNA motifs by specific structurally well-defined cohesive interactions (sticky ends) to produce target materials with predictable 3D structure. This method has generated versatile DNA nanostructures including polyhedral catenanes, robust nanomechanical devices, and a variety of periodic and aperiodic arrays in two dimensions. DNA-self-assembled structures have been used as the template for different guest functional molecules such as proteins, metallic nanoparticles, DNA-based nano-devices, and highly conductive nanowires. Regular lattices made of DNA could hold copies of large biological molecules in a highly ordered array for X-ray crystallography to determine their structure, an important step in the “rational” design of drugs. Alternatively, the lattices could serve as scaffolding for nanoelectronic components, either as a working device or...


Stem Loop Conductive Nanowires Staple Strand Streptavidin Interaction Cross Tile 
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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Molecular FoundryLawrence Berkeley National LabBerkeleyUSA
  2. 2.Department of Chemistry and Biochemistry and Biodesign InstituteArizona State UniversityTempeUSA