Abstract
Influence of the central nervous system, in particular of the hypothalamus, on development of obesity has been suspected since the early clinical observations of Babinski (1900), Fröhlich (1901), and Biedl (1916). Experiments reported by Smith (1927, 1930) showed that injections of chromic acid into the suprasellar region of rats with lesion of the hypothalamus induced obesity in rats (Bomskov 1939). Hetherington and Ranson (1939) found that electrolytic lesions, restricted to the ventromedial region of the hypothalamus, could be associated with the development of obesity.
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References and Further Reading
General Considerations
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Herling, A.W. (2014). Methods to Induce Experimental Obesity. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_72-1
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DOI: https://doi.org/10.1007/978-3-642-27728-3_72-1
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