Methods to Induce Experimental Obesity

  • Andreas W. Herling
Living reference work entry


Influence of the central nervous system, in particular of the hypothalamus, on development of obesity has been suspected since the early clinical observations of Babinski (1900), Fröhlich (1901), and Biedl (1916). Experiments reported by Smith (1927, 1930) showed that injections of chromic acid into the suprasellar region of rats with lesion of the hypothalamus induced obesity in rats (Bomskov 1939). Hetherington and Ranson (1939) found that electrolytic lesions, restricted to the ventromedial region of the hypothalamus, could be associated with the development of obesity.


Brown Adipose Tissue Test Article Hypothalamic Lesion Cafeteria Diet Physiol Regul Integr Comp 
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References and Further Reading

General Considerations

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Diet-Induced Obesity (DIO) in Mice

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Diet-Induced Obesity (DIO) in Rats

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Hypothalamic Obesity

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Chemically Induced Obesity

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Sanofi-Aventis Deutschland GmbHFrankfurtGermany

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