Liver Function

  • Andreas W. Herling
Living reference work entry


The Long-Evans Cinnamon strain of rats has been recommended as a useful model to study genetically transmitted fulminant hepatitis and chronic liver disease (Yoshida et al. 1987; Hawkins et al. 1995). The underlying cause is thought to be due to excessive copper accumulation in the liver of Long-Evans Cinnamon rats, thus making this animal a model for Wilson’s disease in humans (Okayasu et al. 1992). Chelation therapy or feeding a copper-deficient diet can ameliorate the symptoms in Long-Evans Cinnamon rats and Wilson’s disease (Togashi et al. 1992).


Liver Fibrosis Bile Duct Ligation Hepatic Ischemia Prolyl Hydroxylase Activity Induce Liver Cirrhosis 
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References and Further Reading

Hepatitis in Long-Evans Cinnamon Rats

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Temporary Hepatic Ischemia

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Liver Cirrhosis and Necrosis

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Inhibition of Proline Hydroxylation

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Influence on Collagen Synthesis in Human Skin Fibroblasts

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Influence on Collagen Synthesis in Chicken Calvaria

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Allyl Alcohol Induced Liver Necrosis in Rats

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Carbon Tetrachloride Induced Liver Fibrosis in Rats

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Bile Duct Ligation Induced Liver Fibrosis in Rats

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Galactosamine Induced Liver Necrosis

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Liver Fibrosis Induced by Schistosome Cercariae

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Sanofi-Aventis Deutschland GmbHFrankfurtGermany

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