Peripheral Analgesic Activity

  • Vino Daniel
Living reference work entry


The differentiation between central and peripheral analgesic drugs is nowadays of more or less historical value. Most of the so-called peripheral analgesics possess anti-inflammatory properties and in some cases also antipyretic activity besides analgesia. For many of them, the mode of action has been elucidated as an inhibition of cyclooxygenase in the prostaglandin pathway. Nevertheless, new peripheral analgesics have to be tested not only for their in vitro activity on cyclooxygenase but also for their in vivo activity.


Nerve Growth Factor Excitatory Amino Acid Chronic Constriction Injury Visceral Pain Mechanical Hyperalgesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References and Further Reading

Writhing Tests

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Effect of Analgesics on Spinal Neurons

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Antagonism to Nerve Growth Factor

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In Vitro Assays of Nerve Growth Factor

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In Vivo Assays of Nerve Growth Factor Antagonism

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Pfizer IncNew jerseyUSA

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