Methods to Induce Experimental Hypertension

  • Michael Gralinski
  • Liomar A. A. Neves
  • Olga Tiniakova
Living reference work entry


Since the classical experiments of Goldblatt et al. (1934), there is clear evidence that the ischemia of the kidneys causes elevation of blood pressure by activation of the renin–angiotensin system. The principle can be used both for acute and chronic hypertension. In rats acute renal hypertension is induced by clamping the left renal artery for 4 h. After reopening of the vessel, accumulated renin is released into circulation. The protease renin catalyzes the first and rate-limiting step in the formation of angiotensin II leading to acute hypertension. The test is used to evaluate antihypertensive activities of drugs.


Pulmonary Hypertension Portal Hypertension Renal Hypertension Neurogenic Hypertension Pharmacol Toxicol Method 
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References and Further Reading

Acute Renal Hypertension in Rats

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Chronic Renal Hypertension in Rats

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Fructose Induced Hypertension in Rats

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Genetic Hypertension in Rats

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Hypertension Induced by Chronic Angiotensin II Infusion

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Hypertension Induced by Chronic NO-Synthase Inhibition

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Michael Gralinski
    • 1
  • Liomar A. A. Neves
    • 1
  • Olga Tiniakova
    • 1
  1. 1.CorDynamics, Inc.ChicagoUSA

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