Antitussive Activity

  • Kristy D. Bruse
Living reference work entry


Cough is thought to be caused by a reflex. The sensitive receptors are located in the bronchial tree, particularly in the bifurcation of the trachea. These receptors can be stimulated mechanically or chemically, e.g., by inhalation of various irritants. Nerve impulses then activate the cough center in the brain. Several animal species and several irritants have been used, most frequently the citric acid–induced cough in guinea pigs (Charlier et al. 1961; Karlsson et al. 1989; Braga et al. 1993). The pharmacology of cough was reviewed by Reynolds et al. (2004).


Forced Expiration Antitussive Effect Antitussive Agent Antitussive Drug Antitussive Activity 
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References and Further Reading

Antitussive Activity After Irritant Inhalation in Guinea Pigs

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Cough Induced by Mechanical Stimulation

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Cough Induced by Stimulation of the Nervus Laryngicus Superior

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Integrated Physiology & Pharmacology Consulting, LLCPoughkeepsieUSA

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