Binding Tests in Respiratory System

  • Kristy D. Bruse
Living reference work entry


Histamine receptors have been classified on the basis of pharmacological analysis (Hill et al. 1997). Histamine exerts its action via at least four receptor subtypes. The H1 receptor couples mainly to Gq/11, thereby stimulating phospholipase C, whereas the H2 receptor interacts with Gs to activate adenylyl cyclase. The histamine H3 and H4 receptors couple to Gi proteins to inhibit adenylyl cyclase and to stimulate MAPK (Hough 2001).


Chronic Obstructive Pulmonary Disease Muscarinic Receptor Adenylyl Cyclase Histamine Receptor Tiotropium Bromide 
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References and Further Reading

Histamine (H1) Receptor Binding

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Muscarinic Receptor Binding

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Integrated Physiology & Pharmacology Consulting, LLCPoughkeepsieUSA

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