Impact of Functionality on Safety Risk Assessment

  • Bobbie Bradford
Living reference work entry


The functionality of a food/food ingredient may affect both the hazard characterization and the consumer exposure to the food/food product. The amount, frequency of intake, and pattern of exposure may be altered compared with that historically observed for similar foods, or the functional food may be delivered using a novel product type. These aspects must all be considered as they may impact upon the safety risk assessment.


Functional Food Fermented Milk Reproductive Toxicity Receptor Binding Assay Fermented Milk Product 
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References and Further Reading

  1. Chen MN, Lin CC, Liu CF (2014a) Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric 17:1–10CrossRefGoogle Scholar
  2. Chen Y, Liu W, Xue J, Yang J, Chen X, Shao Y, Kwok LY, Bilige M, Mang L, Zhang H (2014b) Angiotensin-converting enzyme inhibitory activity of Lactobacillus helveticus strains from traditional fermented dairy foods and antihypertensive effect of fermented milk of strain H9. J Dairy Sci 97(11):6680–6692CrossRefPubMedGoogle Scholar
  3. Dent MP, O’Hagan S, Braun WH, Schaetti P, Marburger A, Vogel O (2007) 90-day subchronic toxicity study and reproductive toxicity studies on ACE-inhibiting lactotripeptide. Food Chem Toxicol 45:1468–1477CrossRefPubMedGoogle Scholar
  4. Gordon RY, Becker DJ (2011) The role of red yeast rice for the physician. Curr Atheroscler Rep 13:73–80CrossRefPubMedGoogle Scholar
  5. Safford B, Dickens A, Halleron N, Briggs D, Carthew P, Baker V (2003) A model to estimate the oestrogen receptor mediated effects from exposure to soy isoflavones in food. Regul Toxicol Pharmacol 38:196–209CrossRefPubMedGoogle Scholar
  6. Tallon (2009) Probiotics success strategies in food and drinks novel applications, future R&D and consumer engagement. Business Insights.

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.UnileverMilton KeynesUK

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