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Ichthyosis Models

  • Howard Maibach
Living reference work entry

Abstract

Ichthyosis vulgaris is a heterogeneous autosomal skin disease characterized by dry, scaly skin, mild hyperkeratosis, and a decreased or absent granular layer that either lacks or contains morphologically abnormal, keratohyalin granula (Anton-Lamprecht and Hofbauer 1972). Both the skin of ichthyosis vulgaris patients and keratinocytes cultured from affected individuals exhibit reduced or absent profilaggrin mRNA and protein levels (Sybert et al. 1985). The symptoms and the genetics of the ichthyotic (ic/ic) mouse were described by Spearman (1960), Green et al. (1974), Jensen and Esterly (1977), and Holbrook (1989). Presland et al. (2000) demonstrated loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice and proposed this as an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris.

Keywords

Hairless Mouse Topical Retinoid Comparative Potency Single Gene Model Scaly Skin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References and Further Reading

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of DermatologyUC San FranciscoSan FranciscoUSA

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