Respiratory Function Assays in Safety Pharmacology

  • Dennis J. Murphy
Reference work entry


The objectives of a safety pharmacology study of the respiratory system are to determine whether a drug has the potential to produce a change in respiratory function and to establish whether this change is a liability. Such changes can result from either the primary or secondary pharmacological properties of a drug or from organ dysfunction resulting from the toxicological properties of a drug.


Inspiratory Flow Ventilatory Parameter Pleural Pressure Differential Pressure Transducer Sodium Cyanide 
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I would like to thank Jonathan Renninger for his many technical and scientific contributions and Robert Coatney for his surgical contributions to the development of the respiratory models used in our laboratory.

References and Further Reading

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Safety PharmacologyGlaxoSmithKline PharmaceuticalsKing of PrussiaUSA

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