Respiratory Function Assays in Safety Pharmacology
The objectives of a safety pharmacology study of the respiratory system are to determine whether a drug has the potential to produce a change in respiratory function and to establish whether this change is a liability. Such changes can result from either the primary or secondary pharmacological properties of a drug or from organ dysfunction resulting from the toxicological properties of a drug.
KeywordsInspiratory Flow Ventilatory Parameter Pleural Pressure Differential Pressure Transducer Sodium Cyanide
I would like to thank Jonathan Renninger for his many technical and scientific contributions and Robert Coatney for his surgical contributions to the development of the respiratory models used in our laboratory.
References and Further Reading
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- Martin JT, Perez W, Guenther SM, Lodato RF, Dantzker DR (1987) Does rib cage-abdominal paradox signify respiratory muscle fatigue? J Appl Physiol 63(2):851–860Google Scholar
- Nuzzo PF, Anton WR (1986) Practical applications of capnography. Respir Ther 16:12–17Google Scholar
- Pennock BE, Cox CP, Rogers RM, Cain WA, Wells JH (1979) A noninvasive technique for measurement of changes in specific airway resistance. J Appl Physiol 46:39–406Google Scholar