Physicochemical Properties

  • Heiko Tietgen
  • Michael Walden


Characterization of physicochemical properties attained strong interest in the pharmaceutical research area and is now a standard method. It is one of the key challenges to develop a pharmaceutical active ingredient into a drug, which combines biological activity with an appropriate physicochemical profile. Poor solubility in aqueous media is one of the major hurdles in the drug development process. Many promising drug candidates have failed simply due to inadequate solubility. The impact of solubility in drug discovery on biological assays, dosing and formulation, and intestinal absorption is discussed by Kerns et al. (2008).


Partition Coefficient Drug Discovery Shake Flask Experiment Pharm Biomed Anal Oral Drug Absorption 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Sanofi Deutschland GmbHFrankfurt am MainGermany

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