Distribution - In Vitro Tests - Protein Binding

  • Jens Riedel


The protein binding plays an important role in the pharmacokinetics and pharmacodynamics of a drug. Plasma binding can also be viewed as a circulating site of storage, releasing the drug to tissue with higher affinity. Only the unbound drug is thought to be able to diffuse across membranes and to interact with an effector site to produce a therapeutic response.


Human Serum Albumin Plasma Protein Binding Free Fraction Insulin Aspart Unbind Fraction 
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References and Further Reading

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Sanofi Deutschland GmbHFrankfurt am MainGermany

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