Bioanalytical Assays LC-MS/MS

  • Joern Krause
  • Ronald Schmidt
Reference work entry


Powerful analytical techniques are one key requirement for successful drug research and development. The concentration of drugs, prodrugs, and metabolites has to be determined in very diverse matrices such as plasma (blood), urine, feces, and also in different organ tissues (depending on the nature of the drug and on the targeted organs).


Solid Phase Extraction Matrix Effect Quality Control Sample Acceptance Criterion Atmospheric Pressure Chemical Ionization 
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References and Further Reading

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Sanofi Deutschland GmbHFrankfurt am MainGermany
  2. 2.Sanofi Deutschland GmbH, R&D DSAR / Drug Disposition FF, Industriepark HöchstFrankfurt am MainGermany

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