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Absorption: In Vitro Tests – Non Cell Based

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Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

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Abstract

The ability to permeate a biological membrane is a prerequisite for oral administered drugs. The primary absorption pathway for the majority of drugs after oral dosage still seems to be the passive transcellular diffusion pathway. A number of methods used in pharmaceutical research to early on estimate the passive absorption potential of a compound by means of a variety of cell free techniques like reversed phase HPLC, artificial membranes or liposomes and PAMPA are described.

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  1. Sanofi Deutschland GmbH, Industriepark Hoechst, Frankfurt am Main, Germany

    Dr. Markus Kohlmann

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  1. Dr. Markus Kohlmann
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  1. Sanofi Pharma Deutschland GmbH, A company of the Sanofi-Aventis Group Industriepark Hoechst, Frankfurt am Main, Germany

    Jochen Maas

  2. Dieburg, Germany

    Franz J. Hock

  3. Idstein, Germany

    Dieter Mayer

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Kohlmann, M. (2013). Absorption: In Vitro Tests – Non Cell Based. In: Vogel, H.G., Maas, J., Hock, F.J., Mayer, D. (eds) Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25240-2_32

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