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Absorption: In Vitro Tests – Cell Based

  • Katharina Mertsch
Reference work entry

Abstract

In the pharmaceutical industry, we observed a change in paradigm during the 1990s: project teams focused their search for potent compounds not exclusively on potency and specificity—they added pharmaceutical, biopharmaceutical, pharmacokinetic, metabolic, and toxicological characteristics for the most interesting compounds as well. The motivation to characterize compounds for a set of pharmacokinetic and toxicological parameters was driven not only by economic reasons. The number of hits from combinatorial and other chemical libraries raised the necessity to increase quality of nominated drug candidates to reduce the attrition rate in preclinical and clinical stages of project development. Nearly all pharmaceutical companies introduced an expanded assessment for drugability and developability of compounds at the stage of lead selection and lead optimization (Borchardt et al. 1998).

Keywords

Efflux Transporter Breast Cancer Resistance Protein Permeability Test Organic Cation Transporter Organic Anion Transporter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References and Further Reading

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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Sanofi Deutschland GmbHFrankfurt am MainGermany

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