Biomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic Acids, and Mammalian Cells

  • Larry R. Brown


The use of biomaterials to enable and enhance life-saving therapies in medicine has its documented roots in the 1600s. Historically, drugs were administered systemically for acute emergency situations. As injectable drug technologies developed, it was soon observed that drug administration would often be more effective if given in sustained-release or tailored-release profiles. However, the potential safety risks of drugs administered by these novel devices and biomaterials were also quickly realized. This chapter will examine the documented evolution of the delivery of such compounds, the challenges encountered, and the solutions developed to address the need for safe delivery of drugs, proteins, and cells for human use. Each biomaterial-based drug delivery system is unique to the drug, peptide, or protein employed in the system. Therefore, this chapter will focus on the safety considerations along with the therapeutic efficacy offered by this evolving developing area of therapeutics.


Human Insulin Insulin Glargine Therapeutic Protein Insulin Analogue Insulin Detemir 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.MITCambridgeUSA

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