Magnetic Resonance Imaging in Pharmaceutical Safety Assessment

Reference work entry


The high rate of attrition of drug projects through the pharmaceutical pipeline is a significant contributor to the increasing R&D costs seen in recent years. In 2004, the FDA released a report entitled “Innovation or Stagnation, Challenge and Opportunity on the Critical Path to New Medical Products” in which the alarm was raised that only 8% of the molecules that enter clinical development were successfully registered ( Recent data suggests that this figure had fallen to 4% by 2010 (Bunnage 2011). Many more fail in the preclinical stages of development. There is an urgent need for new tools to improve drug development, and the critical path document specifically highlights imaging as one of the new technologies that have a potential to contribute. One quote from the report is particularly telling, “Often, developers are forced to use the tools of the last century to evaluate this century’s advances.”


Magnetic Resonance Spectroscopy Hepatic Steatosis Liver Volume Good Laboratory Practice Lumen Volume 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.PHB Imaging AstraZenecaMölndalSweden

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