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Skin Pharmacology

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Book cover Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

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Abstract

PURPOSE AND RATIONALE

Percutaneous absorption, also known as dermal or skin absorption, is a term that refers to the transport of a chemical from the outermost layer of the skin (stratum corneum) to the systemic circulation. Percutaneous absorption assays are essential for the safety assessment of chemicals making contact with the skin surface, such as pesticides, topically applied pharmaceuticals, industrial chemicals, and cosmetics, as well as in the development of drugs for dermal or transdermal application.

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Author information

Authors and Affiliations

  1. Department of Dermatology, UC San Francisco, 90 Medical Center Way, Surge 110, 0989, San Francisco, CA, 94143-0989, USA

    Dr. Thais H. Sakuma, Dr. Hongbo Zhai & Dr. Howard Maibach

Authors
  1. Dr. Thais H. Sakuma
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  2. Dr. Hongbo Zhai
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  3. Dr. Howard Maibach
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Correspondence to Thais H. Sakuma .

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Editors and Affiliations

  1. Sanofi Pharma Deutschland GmbH, A company of the Sanofi-Aventis Group Industriepark Hoechst, Frankfurt am Main, Germany

    Jochen Maas

  2. Dieburg, Germany

    Franz J. Hock

  3. Idstein, Germany

    Dieter Mayer

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© 2013 Springer-Verlag Berlin Heidelberg

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Sakuma, T.H., Zhai, H., Maibach, H. (2013). Skin Pharmacology. In: Vogel, H.G., Maas, J., Hock, F.J., Mayer, D. (eds) Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25240-2_17

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