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Biological Activities of Selected Mono- and Sesquiterpenes: Possible Uses in Medicine

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Natural Products

Abstract

Reports on the biological properties of mono- and sesquiterpenes (MTs and SQTs) have been on the increase. Although MTs and SQTs are already in wide use as flavoring and antimicrobial agents in cosmetics, perfumes, household and cleansing products, and food additives, many of their pharmacological properties are yet to be discovered. Studies report on their anticancer, antiinflammatory, antinociceptive, antidiabetic, and antimicrobial activities and effects on the central nervous system that make them potential targets for development of new therapeutics and for usage for medical purposes. This chapter provides an overview of the biological activities and aromatherapeutic uses of chemical classes of MTs and SQTs, compiling the scientific achievements mainly from 2010, 2011, and the first part of 2012. Because hundreds of MTs and SQTs and their derivates exist, only some prominent representatives of MT- and SQT-hydrocarbons, -alcohols, -oxides and -carbonyls are discussed.

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Abbreviations

AC:

Adenylate cyclase

AUC:

Area under the plasma level/time curve

cAMP:

Cyclic adenosine monophosphate

CAT:

Catalase

CB receptor:

Cannabinoid receptor

CDK:

Cyclin-dependent kinase

CNS:

Central nervous system

COX:

Cyclooxygenase

CREB:

cAMP response element-binding

CYP:

Cytochrome P450

E-BCP:

(E)-β-Caryophyllene

EO:

Essential oil

ER:

Endoplasmic reticulum

ERK:

Extracellular signal-regulated kinase

GABA:

Gamma-aminobutyric acid

GI:

Gastro-intestinal

HepG2:

Human hepatocellular liver carcinoma

HMG-CoA:

3-Hydroxy-3-methylglutaryl-coenzyme A

IL:

Interleukin

JNK:

C-Jun N-terminal kinase

KATP+ :

ATP-dependent potassium channels

L-NAME:

N-(ω)-nitro-l-arginine methyl ester

LPO:

Lipid peroxidation

LPS:

Lipopolysaccharide

MAPK:

Mitogen-activated protein kinase

MAPK p38:

Mitogen-activated protein kinase p38

MDA:

Membrane lipid peroxidation

MPO:

Myeloperoxidase

MT:

Monoterpene

NMDA:

N-methyl-d-aspartate

NFkB:

Nuclear factor “kappa-light-chain-enhancer” of activated B-cells

NO:

Nitric oxide

NOS:

Nitric oxide synthase

PG:

Prostaglandin

ROS:

Reactive oxygen species

SOD:

Superoxide-dismutase

SQT:

Sesquiterpene

TNF-α:

Tumor necrosis factor alpha

TRP:

Transient receptor potential

TRPA1:

TRP Ankyrin 1

TRPM8:

TRP Melastatin 8

TRPV1:

TRP Vanilloid 1

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  1. Department of Clinical Pharmacy and Diagnostics, Center of Pharmacy, University of Vienna, Althanstrasse 14, Vienna, 1090, Austria

    Prof. Gerhard Buchbauer & Dr. Anja Ilic

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  1. Prof. Gerhard Buchbauer
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  2. Dr. Anja Ilic
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  1. Botany Department, M.L. Sukhadia University, Durga Nursery Road, Udaipur, 313001, Rajasthan, India

    Kishan Gopal Ramawat

  2. Institute of Vine and Wine Sciences, Biological-Active Plant Substances Study, University of Bordeaux, 210 Chemin de Leysotte CS 50008, Villenave d'Ornon, 33882, France

    Jean-Michel Mérillon

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Buchbauer, G., Ilic, A. (2013). Biological Activities of Selected Mono- and Sesquiterpenes: Possible Uses in Medicine. In: Ramawat, K., Mérillon, JM. (eds) Natural Products. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22144-6_183

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