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Natural Products pp 3345–3366Cite as

Quassinoids: Chemistry and Novel Detection Techniques

Abstract

Natural products play a dominant role in pharmaceutical industry, providing resources for the discovery of new drug molecules. Quassinoids are degraded triterpenes reported from the members of the Simarouboidaea subfamily of Simaroubaceae. The importance of quassinoids as antiplasmodial, anticancer and anti-HIV compounds has revived interest in them as potential drug candidates. Its efficacy as combinatorial drug coupled with the structure–activity analysis has reclaimed novel structural leads for new drug development. Quassinoids are categorized into five distinct groups according to their basic skeleton, viz., C-18, C-19, C-20, C-22, and C-25. This present entry reviews the structure, structure–activity relationship, and methods of isolation, detection, and characterization of quassinoids. Recent LC–MS/MS-based techniques could effectively provide more lead molecules which would act in synergism with other compounds.

Keywords

  • Mass spectrometry
  • quantitative structure–activity relationship
  • Quassinoid

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Abbreviations

ESI:

Electrospray ionization

GABA:

Gamma-aminobutyric acid

GC:

Gas chromatography

HIV:

Human immunodeficiency virus

HPLC:

High-performance liquid chromatography

LC:

Liquid chromatography

MALDI:

Matrix-assisted laser desorption/ionization

MS:

Mass spectrometry

NMR:

Nuclear magnetic resonance

QESAR:

Quantitative electronic structure–activity relationship

QSAR:

Quantitative structure–activity relationship

SAR:

Structure–activity relationship

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Authors and Affiliations

  1. Department of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, India

    Dipjyoti Chakraborty

  2. Division of Plant Biology, Bose Institute, Kolkata, West Bengal, 700054, India

    Prof. Amita Pal

Authors
  1. Dipjyoti Chakraborty
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  2. Prof. Amita Pal
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Correspondence to Dipjyoti Chakraborty .

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Editors and Affiliations

  1. Botany Department, M.L. Sukhadia University, Durga Nursery Road, Udaipur, 313001, Rajasthan, India

    Kishan Gopal Ramawat

  2. Institute of Vine and Wine Sciences, Biological-Active Plant Substances Study, University of Bordeaux, 210 Chemin de Leysotte CS 50008, Villenave d'Ornon, 33882, France

    Jean-Michel Mérillon

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Chakraborty, D., Pal, A. (2013). Quassinoids: Chemistry and Novel Detection Techniques. In: Ramawat, K., Mérillon, JM. (eds) Natural Products. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22144-6_144

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