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Cytokines, Chemokines and Interferons

  • Susanne ModrowEmail author
  • Dietrich Falke
  • Uwe Truyen
  • Hermann Schätzl
Reference work entry

Abstract

In 1935, M. Hoskins, G.M. Findlay and F. MacCallum discovered the phenomenon of interference: animals that were inoculated with avirulent yellow fever viruses were found to be protected against infections with the wild-type virus in the following 24 h. The cause of interference remained unclear for a long time until Alick Isaacs and Jean Lindenmann discovered the substance interferon in infected embryonated chicken eggs in 1957. Initially, it was thought that the defence mechanism mediated by interferon was directed against “foreign nucleic acids”, since interferon could effectively be induced by the double-stranded RNA of reoviruses. However, this effect was not very selective. It soon became apparent that even uninfected cells are affected by interferon and that the administration of interferon to animals can provoke serious adverse side effects. In addition, it also became evident that there is a basal interferon concentration in the organism which is physiologically determined and is sustained by frequent viral infections. Interferons exert many functions in the cell, and fulfil important functions in regulating cell physiological processes.

Keywords

Antiviral Effect Oligoadenylate Synthetase CX3C Chemokines Foreign Nucleic Acid Tumour Necrosis Factor Ligand Superfamily 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading

  1. Allen SJ, Crown SE, Handel TM (2007) Chemokine: receptor structure, interactions, and antagonism. Annu Rev Immunol 25:787–820PubMedCrossRefGoogle Scholar
  2. Bangham CRM, Kirkwood TBL (1993) Defective interfering particles and virus evolution. Trends Microbiol 1:260–264PubMedCrossRefGoogle Scholar
  3. Bonglee S, Esteban M (1994) The interferon-induced double-stranded RNA activated protein kinase induces apoptosis. Virology 199:491–496CrossRefGoogle Scholar
  4. Del Prete G, Romagnani S (1994) The role of TH1 and TH2 subsets in human infectious diseases. Trends Med Microbiol 2:4–6CrossRefGoogle Scholar
  5. Eisenächer K, Steinberg C, Reindl W, Krug A (2007) The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity. Immunobiology 212:701–714PubMedCrossRefGoogle Scholar
  6. Fitzgerald K, O’Neill LA, Gearing A (2001) The cytokine facts book, 2nd edn. Academic, LondonGoogle Scholar
  7. Holland S (ed) (2001) Cytokine therapeutics in infectious diseases. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  8. Kobayashi Y (2008) The role of chemokines in neutrophil biology. Front Biosci 13:2400–2407PubMedCrossRefGoogle Scholar
  9. Levy DE (1995) Interferon induction of gene expression through the Jak-Stat pathway. Semin Virol 6:181–89CrossRefGoogle Scholar
  10. Matsuzaki G, Umemura M (2007) Interleukin-17 as an effector molecule of innate and acquired immunity against infections. Microbiol Immunol 51:1139–1147PubMedGoogle Scholar
  11. Murphy PM (1994) Molecular piracy of chemokine receptors by herpesviruses. Infect Agents Dis 3:137–154PubMedGoogle Scholar
  12. Onomoto K, Yoneyama M, Fujita T (2007) Regulation of antiviral innate immune responses by RIG-I family of RNA helicases. Curr Top Microbiol Immunol 316:193–205PubMedCrossRefGoogle Scholar
  13. Oritani K, Kanakura Y (2005) IFN-zeta/limitin: a member of type I IFN with mild lympho-myelosuppression. J Cell Mol Med 9:244–254PubMedCrossRefGoogle Scholar
  14. Pestka S, Krause CD, Walter MR (2004) Interferons, interferon-like cytokines, and their receptors. Immunol Rev 202:8–32PubMedCrossRefGoogle Scholar
  15. Schön MP, Schön M (2007) Imiquimod: mode of action. Br J Dermatol 157:8–13PubMedCrossRefGoogle Scholar
  16. Takeuchi O, Akira S (2008) MDA5/RIG-I and virus recognition. Curr Opin Immunol 20:17–22PubMedCrossRefGoogle Scholar
  17. Thomson A (2003) The cytokine handbook, 4th edn. Academic, LondonGoogle Scholar
  18. Unterholzner L, Bowie AG (2008) The interplay between viruses and innate immune signalling: recent insights and therapeutic opportunities. Biochem Pharmacol 75:589–602PubMedCrossRefGoogle Scholar
  19. Uzé G, Monneron D (2007) IL-28 and IL-29: newcomers to the interferon family. Biochimie 89:729–734PubMedCrossRefGoogle Scholar
  20. Zhang SY, Jouanguy E, Sancho-Shimizu V, von Bernuth H, Yang K, Abel L, Picard C, Puel A, Casanova JL (2007) Human Toll-like receptor-dependent induction of interferons in protective immunity to viruses. Immunol Rev 220:225–236PubMedCrossRefGoogle Scholar
  21. Zlotnik A, Yoshie O, Nomiyama H (2006) The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol 7:243PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Susanne Modrow
    • 1
    Email author
  • Dietrich Falke
    • 2
  • Uwe Truyen
    • 3
  • Hermann Schätzl
    • 4
  1. 1.Inst. Medizinische, Mikrobiologie und HygieneUniversität RegensburgRegensburgGermany
  2. 2.MainzGermany
  3. 3.Veterinärmedizinische Fak., Inst. Tierhygiene undUniversität LeipzigLeipzigGermany
  4. 4.Helmholtz Zentrum München, Institut für VirologieTU MünchenMunichGermany

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