• Susanne ModrowEmail author
  • Dietrich Falke
  • Uwe Truyen
  • Hermann Schätzl
Reference work entry


Pathogenesis describes the spread of a virus in the organism and the mutual relationship between the pathogen and its host during infection. These processes can be analysed in several ways by using different histological, virological and immunological methods. Viral infections can be with or without symptoms (also called apparent or inapparent infection courses). In both cases, the host organism responds with immunological defence responses, which usually lead to overcoming the primary disease symptoms and to the elimination of the virus. The immune response may also contribute in the context of immunopathogenesis to specific disease symptoms and either temporary or permanent damage to the host.


Human Immunodeficiency Virus Respiratory Syncytial Virus Rabies Virus Measle Virus Classical Swine Fever Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading

  1. Arias IM (1990) The biology of hepatic endothelial cell fenestrae. In: Popper H, Schaffner F (eds) Progress in liver diseases IX. WB Saunders, London, pp 11–26Google Scholar
  2. Hardwick JM (1997) Virus-induced apoptosis. Adv Pharmacol 41:295–336PubMedCrossRefGoogle Scholar
  3. Krstic RV (1988) Die Gewebe des Menschen und der Säugetiere, 2nd edn. Springer, HeidelbergCrossRefGoogle Scholar
  4. Mims CA, Playfair JHL, Roitt JM, Wakelin D, Williams R (1998) Medical microbiology, 2nd edn. Mosby, St LouisGoogle Scholar
  5. Murphy FA, Gibbs EPJ, Horzinek MC, Studdert MJ (1999) Veterinary virology, 3rd edn. Academic, San DiegoGoogle Scholar
  6. Nathanson N, Ahmed R, Gonzales-Scarano F, Griffin DE, Holmes KV, Murphy FA, Robinson HL (1997) Viral pathogenesis. Lippincott-Raven, PhiladelphiaGoogle Scholar
  7. Oldstone MBA (1990) Animal virus pathogenesis. A practical approach. IRL, OxfordGoogle Scholar
  8. Riede U-N, Schaefer H-E (2004) Allgemeine und Spezielle Pathologie, 5th edn. Thieme, StuttgartGoogle Scholar
  9. Rolle M, Mayr A (2006) Medizinische Mikrobiologie, Infektions – und Seuchenlehre, 8th edn. Enke, StuttgartGoogle Scholar
  10. Trump BF, Berezesky IK, Chang SH, Phelps PC (1997) The pathways of cell death: oncosis, apoptosis, and necrosis. Toxicol Pathol 25:82–88PubMedCrossRefGoogle Scholar
  11. White DO, Fenner FJ (1994) Medical virology. Academic, San DiegoGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Susanne Modrow
    • 1
    Email author
  • Dietrich Falke
    • 2
  • Uwe Truyen
    • 3
  • Hermann Schätzl
    • 4
  1. 1.Inst. Medizinische, Mikrobiologie und HygieneUniversität RegensburgRegensburgGermany
  2. 2.MainzGermany
  3. 3.Veterinärmedizinische Fak., Inst. Tierhygiene undUniversität LeipzigLeipzigGermany
  4. 4.Helmholtz Zentrum München, Institut für VirologieTU MünchenMünchenGermany

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