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Viruses with Single-Stranded RNA Genomes and Double-Stranded DNA as an Intermediate Product

  • Susanne ModrowEmail author
  • Dietrich Falke
  • Uwe Truyen
  • Hermann Schätzl
Reference work entry

Abstract

Retroviruses were described for the first time about 100 years ago: in 1908, Vilhelm Ellermann and Oluf Bang demonstrated the transmission of avian leucosis by cell-free filtrates; shortly afterwards, Peyton Rous discovered that avian sarcoma can be transmitted to healthy chickens by using filtered cell-free tumour extracts in 1911. Thanks to this discovery, he was awarded the Nobel Prize in Physiology or Medicine in 1966, and the retrovirus contained in the extracts has been named Rous sarcoma virus. Further evidence that retroviruses may cause tumours was provided by John J. Bittner through his research on the development of malignant mammary neoplasms in mice in 1936. He described mouse mammary tumour virus as the causative agent of the disease. This virus also displayed a previously unknown transmission mode: mouse mammary tumour virus is not only transmitted as an infectious, exogenous particle that is released by the cell (horizontal transmission), but it can also be passed on to the next generation as an endogenous constituent of the genome of germ-line cells (vertical transmission).

Keywords

Human Immunodeficiency Virus Long Terminal Repeat Acquire Immune Deficiency Syndrome Feline Immunodeficiency Virus Bovine Leukaemia Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Susanne Modrow
    • 1
    Email author
  • Dietrich Falke
    • 2
  • Uwe Truyen
    • 3
  • Hermann Schätzl
    • 4
  1. 1.Inst. Medizinische, Mikrobiologie und HygieneUniversität RegensburgRegensburgGermany
  2. 2.MainzGermany
  3. 3.Veterinärmedizinische Fak., Inst. Tierhygiene undUniversität LeipzigLeipzigGermany
  4. 4.Helmholtz Zentrum München, Institut für VirologieTU MünchenMünchenGermany

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