Introduction
The technique of spin trapping was first introduced as a term in the paper by Janzen and Blackburn published in the Journal of the American Chemical Society in 1969 (Janzen and Blackburn 1969) following the publication of an earlier paper in the same journal (Janzen and Blackburn 1968). The technique they developed was the use of an unsaturated compound (C-nitroso or nitrone) to react with the radical(s) to be detected via a free radical addition reaction to give a new radical with a longer lifetime, known as a spin adduct. The unsaturated compound used to trap the radicals is known as the spin trap. The history and development of the technique is covered in a review article (Janzen and Haire 1990). The development of this technique has greatly facilitated the detection of radical intermediates, which would otherwise be difficult to detect. The methods commonly employed with ESR spectroscopy are either the generation of a high steady state radical concentration by...
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Haywood, R. (2013). Spin-Trapping: Theory and Applications. In: Roberts, G.C.K. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16712-6_579
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