Definition
BRCA1-A complex subunit Abraxas; Component of the BRCA1-A complex, a complex that specifically recognizes “Lys-63”xs-linked ubiquitinatedhistones H2A and GammaH2AX at DNA damage sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes “Lys-63”-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
(2011). Abraxas. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_6874
Download citation
DOI: https://doi.org/10.1007/978-3-642-16483-5_6874
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16482-8
Online ISBN: 978-3-642-16483-5
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences