Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab


Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_6874


 BRCA1-A complex subunit Abraxas; Component of the BRCA1-A complex, a complex that specifically recognizes “Lys-63”xs-linked  ubiquitinated histones H2A and  GammaH2AX at  DNA damage sites, leading to target the BRCA1- BARD1 heterodimer to sites of DNA damage at  double strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes “Lys-63”-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. Abraxas and  RAP80 form a BRCA1 protein complex required for the DNA damage response.

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© Springer-Verlag Berlin Heidelberg 2011