Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

ABT-888

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_6759

Definition

ABT-888 is a potent inhibitor of  PARP activity (Fig. 1). It inhibits both, PARP-1 and PARP-2 with K(i)s of 5.2 and 2.9 nmol/L, respectively.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2011