AAMP stands for angio-associated migratory cell protein and its gene is found on chromosome 2q35. HUGO nomenclature symbol is AAMP. AAMP has been conserved in evolution, is distributed intracellularly in many cells and also extracellularly on vascular cells, shares an epitope with motility-related proteins ( alpha-actinin and a fast twitch skeletal muscle protein), and contains potential heparin binding and thrombin cleavage sites. Antibody and antisense studies have indicated compartment (intracellular or extracellular)-specific roles for AAMP in angiogenesis, cell–cell and cell–matrix interactions, and cell migration.
The cDNA derived from mRNA encoding AAMP was originally cloned from a human melanoma cell library (A2058) in a search for migration-related proteins. AAMP has been found in the cytoplasm of many nucleated cells, in an extracellular mesh-like network on monolayers of endothelial and vascular-associated smooth muscle cells, and on the apical...