Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

AAMP

  • Marie E. BecknerEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_6

Definition

AAMP stands for angio-associated migratory cell protein and its gene is found on chromosome 2q35. HUGO nomenclature symbol is AAMP. AAMP has been conserved in evolution, is distributed intracellularly in many cells and also extracellularly on vascular cells, shares an  epitope with motility-related proteins ( alpha-actinin and a fast twitch skeletal muscle protein), and contains potential heparin binding and thrombin cleavage sites. Antibody and antisense studies have indicated compartment (intracellular or extracellular)-specific roles for AAMP in angiogenesis, cell–cell and cell–matrix interactions, and cell migration.

Characteristics

The cDNA derived from mRNA encoding AAMP was originally cloned from a human melanoma cell library (A2058) in a search for migration-related proteins. AAMP has been found in the cytoplasm of many nucleated cells, in an extracellular mesh-like network on monolayers of endothelial and vascular-associated smooth muscle cells, and on the apical...

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References

  1. 1.
    Beckner ME, Krutzsch HC, Stracke ML et al (1995) Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. Cancer Res 55:2140–2149PubMedGoogle Scholar
  2. 2.
    Allander SV, Nupponen NN, Ringner M et al (2001) Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile. Cancer Res 61:8624–8628PubMedGoogle Scholar
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    Adeyinka A, Emberley E, Niu Y et al (2002) Analysis of gene expression in ductal carcinoma in situ of the breast. Clin Cancer Res 8:3788–3795PubMedGoogle Scholar
  4. 4.
    Beckner ME, Jagannathan S, Peterson VA (2002) Extracellular angio-associated migratory cell protein plays a positive role in angiogenesis and is regulated by astrocytes in coculture. Microvasc Res 63:259–269PubMedCrossRefGoogle Scholar
  5. 5.
    Beckner ME, Krutzsch HC, Klipstein S et al (1996) AAMP, a newly identified protein, shares a common epitope with alpha-actinin and a fast skeletal muscle fiber protein. Exp Cell Res 225:306–314PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Pittsburgh School of MedicinePittsburghUSA