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Transduction of Oncogenes

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Synonyms

Oncogene transduction; Retroviral transduction

Definition

Retroviruses are RNA-containing viruses that replicate through a DNA intermediate (provirus) using the enzyme reverse transcriptase. During retroviral replication, which requires integration into the host chromosomal DNA for efficient transcription of viral RNA, some retroviruses have acquired specific cellular oncogenes, usually with multiple modifications, and often with the loss of transacting viral functions. Inclusion of one or more oncogenes in the viral genome then imparts transforming activity on the recombinant virus independent of the site of integration in the cellular genome.

Characteristics

Identification of Cellular Oncogenes

In 1911, Peyton Rous described the isolation of a virus that caused fibrosarcomas in chickens. The Rous sarcoma virus (RSV) subsequently was shown to transform chicken embryos and the surrounding membranes and formed small tumors on the chorioallantoic membrane in proportion to the...

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Transduction of Oncogenes. Fig. 1

References

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Correspondence to Jaquelin P. Dudley .

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© 2011 Springer-Verlag Berlin Heidelberg

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Dudley, J.P., Bhadra, S., Mertz, J.A. (2011). Transduction of Oncogenes. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_5911

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