Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

SWI/SNF

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_5612
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Definition

Highly conserved multiproteic structures involved in the ATP-dependent chromatin remodeling. Among the core subunits of SWI/SNF, hSNF5/INI1 is responsible for the oncogenesis of rhabdoid tumors.

hSNF5/INI1/SMARCB1 Tumor Suppressor Gene

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© Springer-Verlag Berlin Heidelberg 2011