Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

Survivin

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_5607
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Synonyms

Definition

As a structurally unique member of the inhibitor of apoptosis protein (IAP) family, survivin is highly expressed in fetal tissues, but not in most adult tissues. Most human cancers return to the fetal pattern of survivin overexpression, thus suggesting a pivotal role of survivin for tumor cell survival.

Characteristics

The human survivin gene is located on chromosome 17 (band q25) and encompasses 14.796 base pairs that comprise six exons. The coding strand is preceded by a TATA-less promoter and a GC-rich region corresponding to a CpG island. The coding sequence of survivin is largely complementary to the coding strand of the effector cell protease receptor-1 (EPR-1) gene. This suggests that survivin and EPR-1 transcripts originate from duplicated genes that were arranged in opposite orientations. The human survivin gene encodes five different splice variants, which may contribute to...
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References

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    Dc A (2003) Validating survivin as a cancer therapeutic target. Nat Rev Cancer 3(1):46–54CrossRefGoogle Scholar
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    Ambrosini G, Adida C, Altieri DC (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3:917–921PubMedCrossRefGoogle Scholar
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    Caldas H, Jiang Y, Holloway MP et al (2005) Survivin splice variants regulate the balance between proliferation and cell death. Oncogene 24:1994–2007PubMedCrossRefGoogle Scholar
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    Mahotka C, Wenzel M, Springer E et al (1999) Survivin-ΔE × 3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res 59:6097–6102PubMedGoogle Scholar
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    Schwerk C, Schulze-Osthoff K (2005) Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell 19:1–13PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Institute of PathologyHeinrich Heine UniversitätDüsseldorfGermany