Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

Surface Plasmon Resonance

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_5595


Surface plasmon resonance (SPR) is one of several optical phenomena known to occur on two-dimensional metal surfaces (typically gold or silver films) when a total internal reflection of incident light occurs at the interface of two different substances, one with a high refraction index and the other with a low refraction index. The SPR biosensor, which exploits the SPR phenomenon, is a label-free and surface-sensitive spectroscopic system, which utilizes measured changes in the local refraction index upon adsorption. This sensor may be applicable to disease diagnostics and high-throughput screening (HTS) in drug discovery, as well as to studies of biomolecular interaction.


Detection Principle of SPR Biosensor

Surface plasmon polaritons (SPPs), which are also referred to more simply as surface plasmons (SPs), are longitudinal and collective oscillations of electrons occurring on a metal–dielectric interface. The frequency of these longitudinal oscillations is...
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  1. 1.
    Ro HS, Koh BH, Jung SO et al (2006) Surface plasmon resonance imaging protein arrays for analysis of triple protein interactions of HPV, E6, E6AP, and p53. Proteomics 6:2108–2111PubMedCrossRefGoogle Scholar
  2. 2.
    Englebienne P, Van Hoonacker A, Verhas M (2003) Surface plasmon resonance: principles, methods and applications in biomedical sciences. Spectroscopy 17:255–273CrossRefGoogle Scholar
  3. 3.
    Jonsson U, Fagerstam L, Ivarsson B et al (1991) Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology. Biotechniques 11:620–627PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.BioNanotechnology Research CenterKorea Research Institute of Bioscience and BiotechnologyYuseongRepublic of Korea