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Podoplanin

  • Reference work entry
  • First Online:
Encyclopedia of Cancer

Synonyms

E11 antigen, RTI40; gp36; Human podoplanin; Mouse podoplanin; OTS-8, gp38, T1α2, PA2.26, RANDAM-2, Aggrus; Rat podoplanin

Definition

Human podoplanin is a type-1 transmembrane glycoprotein consisting of 162 amino acids, nine of which form the intracellular domain. The extracellular domain is extensively O-glycosylated. Depending on glycosylation, the molecular mass is between 36 and 45 kDa. Podoplanin is physiologically expressed in kidney podocytes, skeletal muscle, placenta, lung, heart, myofibroblasts of the breast and salivary glands, osteoblasts and mesothelial cells, and on the apical surface of alveolar type I cells. Occasionally, focal expression of podoplanin can be found in circumscribed areas of the basal layer of the human epidermis. Podoplanin is also expressed in lymphatic endothelium, but not in blood vessels. Pathological expression of podoplanin is observed in many human cancers, in particular squamous cell carcinomas.

Characteristics

In tumors, podoplanin is...

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References

  1. Hantusch B, Kalt R, Krieger S et al (2007) Sp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cells. BMC Mol Biol 8:20

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  2. Martin-Villar E, Megias D, Castel S et al (2006) Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J Cell Sci 119:4541–4553

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  3. Schacht V, Dadras SS, Johnson LA et al (2005) Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 166:913–921

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  4. Wicki A, Christofori G (2007) The potential role of podoplanin in tumour invasion. Br J Cancer 96:1–5

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  5. Wicki A, Lehembre F, Wick N et al (2006) Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell 9:261–272

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Author information

Authors and Affiliations

  1. Department of Clinical-Biological Sciences, Centre of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland

    Andreas Wicki & Gerhard Christofori

Authors
  1. Andreas Wicki
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  2. Gerhard Christofori
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Corresponding authors

Correspondence to Andreas Wicki or Gerhard Christofori .

Editor information

Editors and Affiliations

  1. University Professor of Genetics, German Cancer Research Center - DKFZ, Heidelberg, Germany

    Manfred Schwab

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© 2011 Springer-Verlag Berlin Heidelberg

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Wicki, A., Christofori, G. (2011). Podoplanin. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_4651

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