Definition
MDM2; a major negative regulator of p53 tumor suppressor. The protein acts as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain of p53 and an inhibitor of p53 transcriptional activation.
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© 2011 Springer-Verlag Berlin Heidelberg
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(2011). Murine Double Minute 2. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_3906
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DOI: https://doi.org/10.1007/978-3-642-16483-5_3906
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Publisher Name: Springer, Berlin, Heidelberg
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Online ISBN: 978-3-642-16483-5
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